Table 1.
Clinicopathological characteristics of CRCs in according to Fn abundance or recurrence status
| Characteristics | All cases | Fn-low/negative | Fn-high | P value | Non-recurrence | Recurrence | P value |
|---|---|---|---|---|---|---|---|
| (n = 94) | (n = 73) | (n = 21) | (n = 49) | (n = 45) | |||
| Age | 0.849 | 0.646 | |||||
| ≥ 60 | 42(44.7%) | 33 (45.2%) | 9 (42.9%) | 23 (46.9%) | 19 (42.2%) | ||
| <60 | 52 (55.3%) | 40 (54.8%) | 12(57.1%) | 26 (53.1%) | 26(57.8%) | ||
| Sex | 0.936 | 0.323 | |||||
| Female | 41 (43.6%) | 32 (43.8%) | 9 (42.9%) | 19 (38.8%) | 22 (48.9%) | ||
| Male | 53 (56.4%) | 41 (56.2%) | 12 (57.1%) | 30 (61.2%) | 23 (51.1%) | ||
| Tumor location | 0.051 | 0.079 | |||||
| Rectum | 54 (57.4%) | 42 (57.5%) | 12 (57.1%) | 23 (46.9%) | 31 (68.9%) | ||
| Distal colon | 23 (24.5%) | 21 (28.8%) | 2 (9.5%) | 16 (32.7%) | 7 (15.6%) | ||
| Proximal colon | 17 (18.1%) | 10 (13.7%) | 7 (33.3%) | 10 (20.4%) | 7 (15.6%) | ||
| Tumor size | 0.156 | 0.131 | |||||
| >4 cm | 41 (43.6%) | 29 (39.7%) | 12(57.1%) | 25 (51.0%) | 16 (35.6%) | ||
| ≤ 4 cm | 53 (56.4%) | 44 (60.3%) | 9 (42.9%) | 24 (49.0%) | 29 (64.4%) | ||
| Differentiation | 0.840 | 0.573 | |||||
| Well/Moderate | 75 (79.8%) | 59 (80.8%) | 16 (76.2%) | 38 (77.6%) | 37 (82.2%) | ||
| Poor | 19 (20.2%) | 14 (19.2%) | 5 (23.8%) | 11 (22.4%) | 8 (17.8%) | ||
| Vascular invasion | 0.874 | 0.003 | |||||
| Positive | 30 (31.9%) | 23 (31.5%) | 7 (33.3%) | 9 (18.4%) | 21 (46.7%) | ||
| Negative | 64 (68.1%) | 50 (68.5%) | 14 (66.7%) | 40 (81.6%) | 24 (53.3%) | ||
| Neural invasion | 0.808 | 0.029 | |||||
| Positive | 22 (23.4%) | 18 (24.7%) | 4 (19.0%) | 7 (14.3%) | 15(33.3%) | ||
| Negative | 72 (76.6%) | 55 (75.3%) | 17 (81.0%) | 42 (85.7%) | 30 (6.7%) | ||
| TNM stage | 0.130 | 0.153 | |||||
| II | 45 (47.9%) | 38 (52.1%) | 7 (33.3%) | 20 (40.8%) | 25 (33.3%) | ||
| III | 49 (52.1%) | 35 (47.9%) | 14 (66.7%) | 29 (59.2%) | 20 (66.7%) | ||
| BIRC3 staining | 0.008 | ||||||
| Positive | 36 (38.3%) | 21 (28.8%) | 15 (71.4%) | 0.000 | 25 (51.0%) | 11 (71.4%) | |
| Negative | 58 (61.7%) | 52 (71.2%) | 6 (28.6%) | 24 (49.0%) | 34 (28.6%) | ||
| TLR4 staining | 0.036 | ||||||
| Positive | 50 (53.2%) | 35 (47.9%) | 15 (71.4%) | 0.057 | 21 (42.9%) | 29 (64.4%) | |
| Negative | 44 (46.8%) | 38 (52.1%) | 6 (28.6%) | 28 (57.1%) | 16 (35.6%) | ||
| Fn abundance | 0.014 | ||||||
| Fn-low/negative | 73 (77.7%) | 43(83.6%) | 30 (71.1%) | ||||
| Fn-high | 21 (22.2%) | 6 (16.4%) | 15 (28.9%) | ||||
Pearson Chi-square test