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. 2019 Jan 10;18:8. doi: 10.1186/s12943-018-0932-8

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© The Author(s). 2019

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Analysis of differentially expressed circRNAs in the tissues from CRC patients with or without liver metastasis by RNA-sequencing. a The scatter plot figuratively expresses the changes in circRNA expression CircRNAs above the top green line and below the bottom green line demonstrated more than a 1.5-fold change between the two compared groups. b The volcano plot was showed the expression profiling between the two groups. The vertical green lines refer to a 2.0-fold (log2 scaled) up-regulation and down-regulation, respectively. The horizontal green line corresponds to a P-value of 0.05 (−log10 scaled). The red points in the plot represent differentially expressed circRNAs with statistical significance. c The amount of the total circRNAs and differentially expressed circRNAs. d CircRNAs were classified by category. e CircRNAs were distributed by located in human chromosomes. f Hierarchical clustering indicates differences in circRNA expression profiling between the two groups