Table IV.
Comparison of clinical characteristics of C0s vs. the C1-C6 CVD patients.
| Characteristics | C0s (n=672) | C1-C6 (n=5,144) | P-value |
|---|---|---|---|
| Age | 56.7±15.0 | 60.2±13.4 | <0.001 |
| BMI | 26.4±4.1 | 27.9±5.2 | <0.001 |
| Female (% of patients) | 62 | 76 | <0.001 |
| Patient spontaneous reporting of health issues | C0s (n=672) (%) | C1-C6 (n=5,144) (%) | P-value |
| Pain | 38.7 | 49.6 | <0.001 |
| Sensation of heavy legs | 41.5 | 69.5 | <0.001 |
| Sensation of swelling | 25.0 | 55.1 | <0.001 |
| Cramps | 28.7 | 40.6 | <0.001 |
| Sensation of burning | 18.2 | 25.7 | <0.001 |
| Telangiectasias | 0.7 | 41.0 | <0.001 |
| Reticular veins | 0.3 | 22.3 | <0.001 |
| Varicose veins | 0.3 | 37.3 | <0.001 |
| Swollen legs | 0.6 | 18.7 | <0.001 |
| Skin modifications | 0.6 | 10.9 | <0.001 |
| Leg ulcer | 0.0 | 2.0 | <0.001 |
| No problem | 0.0 | 3.6 | <0.001 |
| CVD symptoms reported when questioned by physician | C0s (n=672) (%) | C1-C6 (n=5,144) (%) | P-value |
| Pain | 39.0 | 55.3 | <0.001 |
| Sensation of heavy legs | 36.9 | 73.7 | <0.001 |
| Sensation of swelling | 19.0 | 56.6 | <0.001 |
| Cramps | 22.5 | 35.3 | <0.001 |
| Sensation of burning | 16.7 | 25.7 | <0.001 |
| Average number of reported CVD symptoms | C0s (n=672) (%) | C1-C6 (n=5,144) (%) | P-value |
| Spontaneously reported by patient | 1,52±0,83 | 2,40±1,36 | <0.001 |
| Reported by patient when questioned by physician | 1,34±0,72 | 2,47±1,25 | <0.001 |
| Time when CVD symptoms are most intense | C0s (n=103) (%) | C1-C6 (n=4,826) (%) | P-value |
| In the morning | 1.9 | 4.1 | 0.271 |
| After standing a long time | 54.4 | 69.7 | <0.001 |
| In the evening | 64.1 | 65.6 | 0.747 |
| During the night | 14.6 | 24.2 | 0.024 |
| Frequency of CVD symptoms | C0s (n=103) (%) | C1-C6 (n=4,826) (%) | P-value |
| Rarely | 11.7 | 8.2 | 0.209 |
| Occasionally | 54.4 | 34.1 | <0.001 |
| Regularly | 30.1 | 44.4 | 0.004 |
| All the time | 2.9 | 12.4 | 0.004 |
| Risk factors | C0s (n=672) (%) | C1-C6 (n=5,144) (%) | P-value |
| Positive CVD family history | 6.0 | 46.3 | <0.001 |
| Positive CVD family history - relative 1st degree (1 parent)a | 85.0 | 74.5 | 0.130 |
| Positive CVD family history - relative 2nd degreea | 15.0 | 17.2 | 0.710 |
| Positive CVD family history - relative 3rd degreea | 2.5 | 2.9 | 0.871 |
| Smoker | 4.8 | 19.0 | <0.001 |
| Standing <5 h/day | 35.0 | 44.1 | 0.064 |
| Standing 5–10 h/day | 50.5 | 45.6 | 0.327 |
| Standing >10 h/day | 14.6 | 10.3 | 0.158 |
| Sitting <5 h/day | 39.8 | 50.2 | 0.037 |
| Sitting 5–10 h/day | 46.6 | 40.4 | 0.208 |
| Sitting >10 h/day | 13.6 | 9.3 | 0.144 |
| For women only | C0s (%) | C1-C6 (%) | P-value |
| Previous pregnancy | 52.8 | 67.8 | <0.001 |
a
Answers available only for 2,424 patients. CVD, chronic venous disorder; BMI, body mass index.