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. 2018 Dec 3;17(2):1330–1336. doi: 10.3892/etm.2018.7042

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Copyright: © Yu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — miRNA-490-3p induces apoptosis and inhibits proliferation of GC cells. (A) The effect of miRNA-490-3p overexpression and knockdown on both SNU-1 and N87 cell growth was analyzed by cell counting kit-8 assay. The effect of miRNA-490-3p overexpression and knockdown on (B) SNU-1 and (C) N87 colony formation was analyzed. (D) The effect of miRNA-490-3p overexpression and knockdown on apoptosis in GC cells was detected by flow cytometry. *P<0.05 vs. inhibitor-NC, ^#P<0.05 vs. mimics-NC. NC, negative control; GC, gastric cancer; SNU-1 and N87, GC cell lines; inhibitor-NC and mimics-NC, GC cell line (SNU-1 or N87) transfected with miRNA-NC inhibitor; mi-inhibitor, GC cell line (SNU-1 or N87) transfected with miRNA-490-3p inhibitor; mi-mimics, GC cell line (SNU-1 or N87) transfected with miRNA-490-3p mimic.