Skip to main content
. 2018 Dec 31;119(1):128–139. doi: 10.1055/s-0038-1676589

Fig. 4.

Fig. 4

Stimulation of platelets with Zn 2+ ionophores leads to shape change. ( A ) Washed platelet suspensions were stimulated with different concentrations of clioquinol (Cq), pyrithione (Py) or A23187 during which changes in light transmission were monitored using optical aggregometry. Initial downward deflections indicate a reduction in light transmission that are consistent with shape change. Subsequent upward deflections indicate increases in light transmission, consistent with platelet aggregation. The maximum ( B ) and minimum ( C ) extent of aggregation were calculated for each ionophore (▪ Cq, ▵ Py, ○ A23187). Data are mean ± standard error of the mean (SEM) from at least 5 experiments.