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. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: Naunyn Schmiedebergs Arch Pharmacol. 2018 Nov 23;392(1):117–121. doi: 10.1007/s00210-018-1590-5

Fig. 1.

Fig. 1

Effect of HCTZ on phenylephrine cumulative concentration-constriction curv6es of pressurized mouse mesenteric arterioles in vitro. WT (circles) and NCC KO mice (squares) were subjected to restricted Na+ diet. Mesenteric arterioles were then removed, pressurized, and exposed to DMSO (vehicle) followed by cumulative phenylephrine concentrations (closed symbols). Following phenylephrine washout, 100 μM HCTZ and then phenylephrine (open symbols) were added. WT: n = 6 and 3 at ≤ 1 μM and 3 μM phenylephrine, respectively; NCC KO: n = 6. The lower n with 3 μM phenylephrine was due to absence of 3 μM phenylephrine challenge, exclusion of an outlier (≈ two standard deviations from the mean) and when 3 μM phenylephrine failed or minimally constricted the unmaintained constriction to 1 μM phenylephrine