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. 2019 Jan 3;21:101095. doi: 10.1016/j.redox.2018.101095

Fig. 5.

Fig. 5

HSP22 deficiency exacerbates diabetes-induced endothelial injuryin vivo. Diabetes was induced in wild-type (WT) and knockout (KO) mice by HFD adjuvanted with STZ injection for 12 weeks (n = 8 per group). A) Blood glucose concentrations in the WT-control, KO-control, WT-diabetes and KO-diabetes mice were measured at baseline and 4, 8, and 12 weeks after diabetes induction. B) The body weights of the WT-control, KO-control, WT-diabetes and KO-diabetes mice were measured at baseline and 4, 8, and 12 weeks after diabetes induction. C) Representative images of H&E (original magnification ×40). D) Representative immunohistochemical staining images of HSP22, ICAM-1 and VCAM-1 in aortic sections (original magnification ×40). E) Quantification of positive staining for HSP22 in aortic sections. n = 5. F) mRNA expression of HSP22 in the aorta. G) Quantification of positive staining for ICAM-1 and VCAM-1 in aortic sections. n = 5. H) mRNA expression of IL5, IL6, IL13, Mip3α and TGFβ1 in the aorta. *P < 0.05 vs. WT-control; #P < 0.05 vs. WT-diabetes; &P < 0.05 vs KO-control.