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(A) The observation of the escape of GA-Se@DOX from endosomes/lysosomes after 1, 2, and 4 h of incubation. Scale bar is 50 μm. (B) In vitro release of DOX from GA-Se@DOX nanoparticles. **p < .01 vs. pH5.4 group. (C) The cytotoxicity of DOX, Se@DOX, and GA-Se@DOX against HepG2 cells. *p < .05, **p < .01 vs free DOX group. (D) The cytotoxicity of GA-SeNPs against HepG2 cells.
