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IC50 Values of 2,7-anhydro-Neu5TFA (2) and 2,7-anhydro-Neu5Cyclohexyl (4) against bacterial sialidases.
| Sialidases | IC50 values of different inhibitors (μM) |
|
|---|---|---|
| (2) | (4) | |
| SpNanA | 145 ± 16 | 500 − 1000 |
| SpNanB | 250 − 500 | 180 ± 23 |
| SpNanC | > 1000 | 58.4 ± 2.4 |
| AuSialidase | 225 ± 34 | > 1000 |
| VcSialidase | 500 − 1000 | > 1000 |
