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. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: J Allergy Clin Immunol. 2018 Oct 25;143(1):245–257.e6. doi: 10.1016/j.jaci.2018.10.018

FIG 4.

FIG 4.

TGFβ1 rescues survival and proliferation of naïve Gimap5sph/sph CD4+ T cells. Proliferation and survival of naïve WT and Gimap5sph/sph CD4+ T cells after 3d stimulation in (A) TH0 or (B) TH2 polarizing conditions ± 2 ng/mL TGFβ1. Blue histograms represent dead cells; red histograms show live cells. Survival, proliferation, and γH2AX expression of naïve CD4+ T cells stimulated in (C-D) TH0, (E-F) TH1, (G-H) or TH2 polarizing conditions. At 1 or 2 days after initial stimulation, 2 ng/ml TGFβ1 was added to the indicated culture. Data represent mean values ± SD (n=4). Statistical significance is determined by ANOVA followed by Sidak’s multiple comparisons test. *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001