Table 2.
Inhibitory activity of the cyanopyridine scaffold derivatives against purified human IDO1 enzyme.
| Compound | Structure | Enzymatic assay (IC50, μM)a | Compound | Structure | Enzymatic assay (IC50, μM)a |
|---|---|---|---|---|---|
| LBJ-01 |  |
19.5 ± 0.28 | LBJ-09 |  |
5.81 ± 1.20 |
| LBJ-02 |  |
23.1 ± 0.67 | LBJ-10 |  |
0.84 ± 0.33 |
| LBJ-03 |  |
9.14 ± 0.38 | LBJ-11 |  |
9.61 ± 0.71 |
| LBJ-04 |  |
43.6 ± 0.85 | LBJ-12 |  |
17.9 ± 1.28 |
| LBJ-05 |  |
18.0 ± 0.13 | LBJ-13 |  |
23.6 ± 2.11 |
| LBJ-06 |  |
9.76 ± 0.32 | LBJ-14 |  |
35.7 ± 1.25 |
| LBJ-07 |  |
20.6 ± 1.12 | LVS-019 |  |
2.64 ± 0.94 |
| LBJ-08 |  |
1.87 ± 0.83 | GDC-0919 analogue | – | 0.81 ± 0.04 |
aThe IC50 values were the means of more than three independent experiment sets.