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. 2019 Jan 2;34(1):250–263. doi: 10.1080/14756366.2018.1480614

Table 2.

Inhibitory activity of the cyanopyridine scaffold derivatives against purified human IDO1 enzyme.

Compound Structure Enzymatic assay (IC50, μM)a Compound Structure Enzymatic assay (IC50, μM)a
LBJ-01 graphic file with name IENZ_A_1480614_ILG0008_B.gif 19.5 ± 0.28 LBJ-09 graphic file with name IENZ_A_1480614_ILG0016_B.gif 5.81 ± 1.20
LBJ-02 graphic file with name IENZ_A_1480614_ILG0009_B.gif 23.1 ± 0.67 LBJ-10 graphic file with name IENZ_A_1480614_ILG0017_B.gif 0.84 ± 0.33
LBJ-03 graphic file with name IENZ_A_1480614_ILG0010_B.gif 9.14 ± 0.38 LBJ-11 graphic file with name IENZ_A_1480614_ILG0018_B.gif 9.61 ± 0.71
LBJ-04 graphic file with name IENZ_A_1480614_ILG0011_B.gif 43.6 ± 0.85 LBJ-12 graphic file with name IENZ_A_1480614_ILG0019_B.gif 17.9 ± 1.28
LBJ-05 graphic file with name IENZ_A_1480614_ILG0012_B.gif 18.0 ± 0.13 LBJ-13 graphic file with name IENZ_A_1480614_ILG0020_B.gif 23.6 ± 2.11
LBJ-06 graphic file with name IENZ_A_1480614_ILG0013_B.gif 9.76 ± 0.32 LBJ-14 graphic file with name IENZ_A_1480614_ILG0021_B.gif 35.7 ± 1.25
LBJ-07 graphic file with name IENZ_A_1480614_ILG0014_B.gif 20.6 ± 1.12 LVS-019 graphic file with name IENZ_A_1480614_ILG0022_B.gif 2.64 ± 0.94
LBJ-08 graphic file with name IENZ_A_1480614_ILG0015_B.gif 1.87 ± 0.83 GDC-0919 analogue – 0.81 ± 0.04

aThe IC50 values were the means of more than three independent experiment sets.