. 2019 Jan 3;34(1):230–243. doi: 10.1080/14756366.2018.1550085

Table 1.

Results of the in vitro growth inhibition (GI %) caused by compounds 8a, b, d, e, f, h and 11a-c against human cancer cell lines in the single-dose assay^a.

Cell type	Compound	8a	8b	8d	8e	8f	8h	11a	11b	11c
Cell type	Cell line	GI (%) (10⁻⁵M)^a
Leukemia	CCRF-CEM	89	76	23	83	86	4	30	77	11
	K-562	89	78	79	90	90	6	77	94	11
	SR	82	68	72	77	82	18	77	95	27
	HL-60(TB)	100^b (33)	100^b (22)	47	100^b (24)	100^b (17)	11	71	100^b (8)	18
	MOLT-4	81	67	31	82	70	23	38	71	31
	RPMI-8226	79	71	51	82	88	22	18	67	21
Non-small Cell lung cancer	A549/ATCC	76	65	27	73	73	23	45	82	20
	HOP-62	68	69	23	49	52	21	10	57	10
	NCI-H460	90	85	0	90	89	0	49	93	0
	NCI-H522	65	75	84	96	100^b (11)	34	60	97	16
Colon cancer	COLO205	100^b (25)	100^b (13)	29	100^b (39)	100^b (11)	1	40	81	0
	HCT-116	88	86	54	85	75	22	49	96	19
	HCT-15	76	78	30	75	68	8	41	70	23
	HT-29	96	93	40	92	96	27	70	98	0
	SW-620	66	81	60	73	82	6	64	92	1
	KM12	79	72	48	72	70	8	60	84	4
CNS cancer	SF-295	86	72	26	59	76	1	27	91	13
	SF-539	100^b (12)	80	22	85	96	6	13	89	4
	SNB-75	66	76	31	52	82	21	21	100^b (10)	14
	U251	85	75	35	81	77	28	19	100^b (13)	14
Melanoma	LOX IMVI	57	60	9	69	51	11	34	90	4
	M14	96	100^b (16)	45	79	89	0	50	84	6
	MDA-MB-435	100^b (57)	99	88	97	100^b (16)	0	93	96	1
	UACC-62	70	74	39	41	53	7	30	58	1
	SK-MEL-2	42	79	55	72	84	19	22	85	3
	SK-MEL-5	74	74	37	97	69	10	66	81	34
Ovarian cancer	OVCAR-3	100^b (15)	99	22	87	99	0	53	100^b (13)	2
	NCI/ADR-RES	97	93	50	79	81	7	36	81	12
	SK-OV-3	73	80	27	76	94	25	17	62	7
	OVCAR-8	70	62	24	75	70	10	22	66	12
	OVCAR-4	38	38		48	43	19	16	100^b (18)	0
Renal cancer	A498	100^b (5)	100^b (3)	15	77	100^b (2)	7	26	84	18
	ACHN	48	47		51	40	1	21	98	9
	RXF393	100^b (4)	64	25	66	86	21	12	71	10
	TK-10	46	36		22	35	20	3	100^b (9)	15
Breast cancer	MCF7	80	75	51	78	79	12	70	84	14
Breast cancer	MDA-MB-468	100^b (12)	73	22	63	70	8	1	57	5
Prostate cancer	PC-3	78	64	33	69	75	24	45	68	24
Prostate cancer	DU-145	76	63	6	79	78	16	6	54	2

The most active compounds are highlighted in bold.

Data obtained from NCI’s in vitro 60 cell one dose screening at 10⁻⁵M concentration.

Cytotoxic effect; lethality percent is represented in brackets.