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. 2019 Jan 3;34(1):361–374. doi: 10.1080/14756366.2018.1553167

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© 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Structure and biochemical characterisation of diary carboxylic acid derivatives. AC₅₀: compound concentration required for 50% of maximum activation of PDK1; Amax: maximum activation of PDK1 compared to DMSO control (=100%); T308tide: a synthetic substrate peptide in the radioactivity-based kinase assay that does not interact with the PIF-pocket but could be phosphorylated by PDK1.