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(A) Cartoon/surface representations of the interaction between 12 with the PIF-pocket of PDK1 (pale yellow; PDB ID: 3ORZ). (B) Cartoon/surface representations of the interaction between 12 with the PIF-pocket of PDK1 (slate; PDB ID: 3OTU). (C) Comparison of the helix αB and helix αC of PDK1-11 complex, PDK1-12 complex and PDK1-4 complex (salmon). (D) Comparison of the BIM-IIof PDK1-11 complex and PDK1-12 complex.
