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. 2018 Dec 6;3(23):e120706. doi: 10.1172/jci.insight.120706

Figure 2. Endothelial CXCR4 deficiency ameliorated the disruption of BRB.

Figure 2

(A) Representative images of retina immunostaining of isolectin B4 (red) on P8. Scale bar: 500 μm (top); 100 μm (bottom). (B) The effect of endothelial CXCR4 deficiency (Cre+) on PBS- or APB5-treated retinal radius and vessel diameter on P8 (n = 5–6). (C) Representative images of retina immunostaining of isolectin B4 (red) and fibrinogen (green) on P8. Scale bar: 100 μm. (D) The effect of endothelial CXCR4 deficiency (Cre+) on PBS- or APB5-treated retinal fibrinogen intensity on P8 (n = 5–6). (E) Representative images of retina immunostaining of isolectin B4 (red) and F4/80 (green) on P8. Scale bar: 100 μm. (F) The effect of endothelial CXCR4 deficiency (Cre+) on PBS- or APB5-treated retinal F4/80-positive cells on P8 (n = 5–6). Significantly different from the results in Cre– mice at *P < 0.05, significantly different from the results in Cre– mice.