Table 4.
Association between alleles of BsmI, TaqI and FokI with different parameters in patients with βTM.
| VDR genetic variants | BsmI | TaqI | FokI | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||
| Alleles | B | b | p | T | t | p | F | f | p | |
| Age (years) | Mean ± SD. | 9±3.7 | 8.9±3.6 | 0.913 | 8.2±3.5 | 10.1±3.7 | 0.021* | 8.6±3.6 | 9.7±3.8 | 0.198 |
| Sex | Male | 54.4% | 39.1% | 0.217 | 42.6% | 60.6% | 0.112 | 48.1% | 53.8% | 0.633 |
| Female | 45.6% | 60.9% | 57.4% | 39.4% | 51.9% | 46.2% | ||||
| Height Z score | Median (Range) | −0.3 (−2.9 – 0.5) | −1.3 (−3.3 – 0.5) | 0.031* | −0.9 (−2.9 – 0.5) | −0.8 (−3.3 – 0.5) | 0.681 | −0.7 (−3.3 – 0.5) | −1.2 (−3.3 ± 0.3) | 0.344 |
| Weight Z score | Median (Range) | −1 (−3.2 – 0.9) | −1.6 (−3.1 – 0.7) | 0.437 | −1 (−3.1 – 0.9) | −1.3 (−3.2 – 0.9) | 0.278 | −1 (−3.2 – 0.9) | −1.3 (−3.1 – 0.9) | 0.615 |
| BMI Z score | Median (Range) | −0.7 – −4.4 | −0.9 (−2.7 – 2.3) | 0.848 | −0.2 (−3.5 – 2.3) | −0.9 (−4.4 – 2.3) | 0.314 | −0.7 (−4.4 – 2.3) | −1 (−3.5 – 1.5) | 0.774 |
| Ca (mg/dl) | Median (Range) | 8.6(6.8–12.8) | 8.2(7.2–10.3) | 0.011* | 8.5(6.8–10.4) | 8.6(6.8–12.8) | 0.222 | 8.6(6.8–12.8) | 8.6(7.2–12.8) | 0.512 |
| P (mg/dl) | Median (Range) | 5.5(4.1–6.5) | 5.2(4.1–6.4) | 0.037* | 5.7(4.1–6.5) | 5.6(4.1–6.5) | 0.335 | 5.4(4.1–6.5) | 5.7(4.2–6.5) | 0.347 |
| ALP (U/L) | Median (Range) | 175(79–344) | 202(79–345) | 0.088 | 176(79–345) | 179(106–328) | 0.498 | 183.5(79–345) | 170(124–345) | 0.813 |
| S Ferritin | Median (Range) | 1700 (200–4672) | 1930 (900–3935) | 0.530 | 1660 (200–4672) | 2000 (200–4672) | 0.252 | 1815 (200–4672) | 1816 (350–4672) | 0.984 |
| Median (Range) | 26.7(17.1–64.4) | 20.7(16.5–64.4) | 0.006* | 26.7(16.5–64.4) | 23.7(16.5–64.4) | 0.222 | 27.2(16.7–64.4) | 21.5(16.5–41.4) | 0.001* | |
| Deficient | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | ||||
| Vitamin D | Insufficient | 14.0% | 43.5% | 0.004* | 19.1% | 27.3% | 0.392 | 13.0% | 42.3% | 0.003* |
| Sufficient | 86.0% | 56.5% | 80.9% | 72.7% | 87.0% | 57.7% | ||||
| Bone pain | 49.1% | 52.2% | 0.805 | 38.3% | 22 (66.7) | 0.012* | 44.4% | 61.5% | 0.152 | |
| Bone diseases | Fractures | 26.3% | 13% | 0.198 | 12.8% | 12 (36.4%) | 0.013 | 20.4%) | 26.9% | 0.511 |
| Tenderness | 47.4% | 47.8% | 0.970 | 36.2% | 21 (63.6%) | 0.015* | 24 (44.4%) | 53.8% | 0.430 | |
| Median (Range) | −1.9(−4-−1) | −2.4(−6–−1.7) | <0.001* | −2(−4–−1) | −1.9(−6–−1) | 0.754 | −1.9(−6–1) | −2.4(−6–1.1) | <0.001* | |
| Normal | 10.5% | 0% | 6.4% | 9.1% | 11.1% | 0% | ||||
| BMD Z score | Osteopenia | 77.2% | 52.2% | 0.002* | 70.2% | 69.7% | 0.869 | 77.8% | 53.8% | 0.002* |
| Osteoporosis | 12.3% | 47.8% | 23.4% | 21.2% | 11.1% | 46.2% | ||||
*
Statistically significant at p ≤ 0.05.