Table 1.
Three-dimensional crystal structures of CD1 molecules in complex with microbial lipid-based Ags
| Lipid-based Ags | Microbial origin | CD1 isoform | PDB codes | References |
|---|---|---|---|---|
| Mycobactin lipopeptide | Mycobacterium spp. | CD1a | 1XZ0 | [113] |
| Diacylsulfoglycolipid (Ac2SGL) | Mycobacterium tuberculosis | CD1b | 3T8X | [114] |
| Glucose monomycolate-C54 (GMM-C54) | Nocardia spp. | CD1b | 1UQS | [113] |
| Glucose monomycolate-C32 (GMM-C32) | Rhodococcus spp. | CD1b | 5L2J | [112] |
| Mannosyl-β1-phosphomycoketide (MPM) | Mycobacterium tuberculosis | CD1c | 3OV6 | [120] |
| Phosphomycoketide (PM) | Mycobacterium tuberculosis | CD1c | 4ONO | [121] |
| α-Galacturonosylceramide (GalA-GSL) | Sphingomonas spp. | CD1d | 2FIK | [48] |
| α-Galactosyldiacylglycerols (BbGL-2c and BbGL-2f) | Borrelia burgdorferi | CD1d |
3ILQ 3ILP |
[50] |
| α-Glucosyldiacylcerol (αGlcDAG-s2) | Streptococcus pneumoniae | CD1d | 3T1F | [51] |