Skip to main content
. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: Biomaterials. 2018 Apr 3;178:504–516. doi: 10.1016/j.biomaterials.2018.03.059

Figure 1.

Figure 1

A) Overview of the folic acid niche that provides chemical and mechanical cues to enhance functional recovery in a peripheral injury model. B) Cartoon illustrating the detailed mechanism of the multifunctional and dynamic neuroregenerative folic acid niche and how it allows peripheral nerve regeneration by modulating the proliferation and migration of Schwann cells (I, II), stimulating the Schwann cells to release more neurotrophins (III), and increasing mechanical forces in the neurons that in turn boost the axonal regeneration of the neurons (IV and V) and peripheral nerve regeneration (VI).