(A) Mice at 18 months of age were placed in an apparatus that recorded the number of missed steps while walking. The following results are reported as “mean (lower bound of the confidence interval, upper bound of the confidence interval).” (B) Wild-type mice missed 0.4 (0.0, 0.8) steps (n = 8; 4 female, 4 male), DNIIRTg mice missed 1.7 (0.6, 2.7) steps (n = 9; 4 female, 5 male), and DNIIRTg;Prg4Tg mice missed 0.4 (-0.1, 0.8) steps (n = 8; 5 female, 3 male). There were the following statistically significant differences (reported as “mean difference (lower bound of confidence interval, upper bound of confidence interval)”): wild-type and DNIIRTg mice (-1.3 (-2.1, -0.4)) and DNIIRTg and DNIIRTg;Prg4Tg mice (1.3 (0.4, 2.1)).