Table 5. Sensitivity of results to level of CrAg screening and proportion of patients with meningitis treated.
Results | Strategy | Cost of Screening | Cost of preemptive treatment | Cost of treatment for meningitis | Total Cost | Deaths | Note |
---|---|---|---|---|---|---|---|
SA.a | No screening or treatment for CM | 0 | 0 | 0 | 0 | 10075 | Do nothing |
SA.b | No screening, 50% hospitalized (CM treatment with amphotericin + fluconazole) | 0 | 0 | $2,528,052 | $2,528,052 | 6448 | Dominated by SA.d if slightly larger budget possible |
SA.c | No screening, 80% hospitalized. CM treatment with amphotericin + fluconazole | 0 | 0 | $4,044,882 | $4,044,882 | 4272 | Dominated by SA.d and base case |
SA.d | CrAg screening, 50% hospitalized (CM treatment with amphotericin + fluconazole) | $436,314 | $295,431 | $2,078,920 | $2,810,665 | 3538 | CrAg screening with 50% of patients being hospitalized has essentially the same total costs as the same amount of hospitalization without screening (SA.b), but an additional 2,910 lives are saved annually. |
Base case results | CrAg screening, 80% hospitalized (CM treatment with amphotericin + fluconazole) | $436,314 | $295,431 | $2,624,979 | $3,356,724 | 2755 |