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. 2019 Jan 10;14(1):e0210105. doi: 10.1371/journal.pone.0210105

Table 5. Sensitivity of results to level of CrAg screening and proportion of patients with meningitis treated.

Results Strategy Cost of Screening Cost of preemptive treatment Cost of treatment for meningitis Total Cost Deaths Note
SA.a No screening or treatment for CM 0 0 0 0 10075 Do nothing
SA.b No screening, 50% hospitalized (CM treatment with amphotericin + fluconazole) 0 0 $2,528,052 $2,528,052 6448 Dominated by SA.d if slightly larger budget possible
SA.c No screening, 80% hospitalized. CM treatment with amphotericin + fluconazole 0 0 $4,044,882 $4,044,882 4272 Dominated by SA.d and base case
SA.d CrAg screening, 50% hospitalized (CM treatment with amphotericin + fluconazole) $436,314 $295,431 $2,078,920 $2,810,665 3538 CrAg screening with 50% of patients being hospitalized has essentially the same total costs as the same amount of hospitalization without screening (SA.b), but an additional 2,910 lives are saved annually.
Base case results CrAg screening, 80% hospitalized (CM treatment with amphotericin + fluconazole) $436,314 $295,431 $2,624,979 $3,356,724 2755