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. 2019 Jan 10;14(1):e0205618. doi: 10.1371/journal.pone.0205618

Fig 1. T. aquaticus DGR.

Fig 1

The T. aquaticus prophage DGR contains a gene encoding a variable protein (taqvp). The 3’ end of taqvp contains the variable region (VR) and initiation-of-mutagenic homing (IMH) sequence. The DGR also contains an accessory variability determinant (avd) gene, followed by an invariant template region (TR), which differs from VR mainly at adenines. A sequence similar but not identical to the VR IMH occurs at the 3’ end of the TR and is called IMH*. Following these elements is a gene encoding a reverse transcriptase (rt). TR is transcribed to produce TR-RNA, which is reverse transcribed to produce TR-cDNA, with adenine-specific mutagenesis of the sequence accompanying reverse transcription. Adenine-mutagenized TR-cDNA homes to and replaces VR to yield a variant TaqVP.