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. 2019 Jan 10;14(1):e0210389. doi: 10.1371/journal.pone.0210389

Fig 2. Melanotan-II improved sociability index scores but did not affect social novelty scores.

Fig 2

(a) Three-chamber test assessment of sociability index, with results shown for MIA mice pre- and post-vehicle control or pre- and post- MT-II treatment (vehicle, n = 7; MT-II treatment, n = 10). One-way ANOVA comparison between MIA mice treated by vehicle versus MT-II showed a significant treatment interaction between groups: F(3,30) = 19.33; p < 0.0001. Sidak’s multiple comparison test showed no significant increase in sociability index following vehicle administration in MIA mice; p = 0.70. Sidak’s multiple comparison test showed a significant increase in sociability index following MT-II administration in MIA mice; p < 0.0001. (b) Three-chamber test assessment of social novelty index, with results shown for MIA mice pre- and post-vehicle control or MT-II treatment (vehicle, n = 7; MT-II treatment, n = 8). One-way ANOVA comparison between MIA mice treated by vehicle versus MT-II did not show a significant treatment interaction between groups: F(3,26) = 1.28; p = 0.30. Sidak’s multiple comparison test did not show any significant changes in social novelty in the vehicle treated MIA mice; p = 0.23 or the MT-II treated MIA mice; p = 0.55. (a, b): data represented as mean +/- SEM.