Table 4. Diagnostic capabilities of pRNFL, TM, mRNFL and mGCL for differentiating early normal tension glaucoma.

Variables (μm)	Sensitivity at 80% Specificity (%)	Sensitivity at 95% Specificity (%)	AUROC (95%CI)95% CI	p value
pRNFL thickness
Global	80.0	38.2	0.896(0.838–0.954)	<0.001
Superior	77.3	58.3	0.859(0.790–0.928)	<0.001
Inferior	69.8	50.8	0.828(0.753–0.904)	<0.001
Temp-sup	80.0	64.8	0.882(0.820–0.945)	<0.001
Temp-inf	76.5	55.0	0.858(0.789–0.927)	<0.001
Nas-sup	58.0	32.1	0.742(0.650–0.834)	<0.001
Nas-inf	33.3	22.4	0.646(0.543–0.749)	0.009
TML thickness
SOM	72.6	38.2	0.820(0.741–0.899)	<0.001
SIM	44.0	22.4	0.673(0.572–0.774)	0.002
Fovea	16.4	3.3	0.421(0.314–0.528)	0.157
IIM	44.8	22.9	0.671(0.570–0.771)	0.002
IOM	70.3	48.7	0.794(0.710–0.877)	<0.001
Superior	58.3	30.0	0.760(0.670–0.850)	<0.001
Inferior	60.7	33.3	0.753(0.663–0.844)	<0.001
mRNFL thickness
SOM	64.2	49.8	0.810(0.731–0.889)	<0.001
SIM	34.6	23.0	0.639(0.536–0.742)	0.006
Fovea	12.4	3.8	0.373(0.268–0.479)	0.031
IIM	33.0	16.8	0.621(0.517–0.726)	0.028
IOM	68.5	53.3	0.840(0.769–0.912)	<0.001
Superior	63.3	42.1	0.782(0.698–0.867)	<0.001
Inferior	59.8	43.0	0.796(0.715–0.877)	<0.001
mGCL thickness
SOM	78.0	49.5	0.863(0.794–0.931)	<0.001
SIM	59.6	27.4	0.747(0.655–0.839)	<0.001
Fovea	11.8	3.3	0.424(0.317–0.532)	0.176
IIM	55.2	44.8	0.747(0.656–0.838)	<0.001
IOM	70.0	48.9	0.837(0.764–0.911)	<0.001
superior	67.6	46.3	0.834(0.760–0.909)	<0.001
Inferior	74.0	48.0	0.836(0.761–0.912)	<0.001

pRNFL: peripapillary retinal nerve fiber layer; TML: total macular layer; mRNFL: macular retinal nerve fiber layer; mGCL: macular ganglion cell layer; Temp-sup: temporal-superior; Temp-inf: temporal-inferior; Nas-sup: nasal-superior; Nas-inf: nasal-inferior; SIM: superior inner macula; IIM: inferior inner macula; SOM: superior outer macula; IOM: inferior outer macula; AUROC: area under the receiver operating characteristic; CI: confidence interval.