Table 3. Quantitative trait analysis of rare missense PPP1R3B variants in n = 2,930 newly-diagnosed patients with T2D.
| Trait | Non-carriers (n = 2,913) Median (IQR) |
Carriers (n = 17) Median (IQR) |
p-value (sex and age adjusted) |
|---|---|---|---|
| Sex (men/women)* | 1664/1174 | 14/3 | _ |
| Age at examination (years) | 61.0 (53.0–68.0) | 55.0 (52.0–61.0) | _ |
| Age at diagnosis (years) | 60.0 (52.0–67.0) | 53.5 (47.0–57.0) | 0.6 |
| BMI (Kg/m2) | 30.6 (27.0–34.6) | 29.7 (27.1–32.6) | 0.8 |
| Waist-hip ratio (cm) | 0.98 (0.92–1.03) | 0.97 (0.94–1.03) | 0.03 |
| s-triglycerides (mmol/L) | 1.60 (1.10–2.40) | 1.70 (1.20–1.80) | 0.6 |
| s-total cholesterol (mmol/L) | 4.40 (3.70–5.10) | 4.65 (4.05–5.93) | 0.3 |
| s-HDLc (mmol/L) | 1.20 (1.00–1.40) | 1.20 (1.03–1.38) | 0.5 |
| s-LDLc (mmol/L) | 2.20 (1.80–2.90) | 3.40 (2.60–3.90) | 0.006 |
Traits were all q-transformed.
* not available in 75 individuals from DD2 (T2D-cohort).
Values in bold are significant p-value. BMI, body mass index; HDLc: HDL-cholesterol; IQR, interquartile range; LDLc: LDL-cholesterol.