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. Author manuscript; available in PMC: 2019 Jan 10.
Published in final edited form as: J Clin Immunol. 2014 Dec 13;35(2):112–118. doi: 10.1007/s10875-014-0116-2

Fig. 1. Lymph node histology and imaging.

Fig. 1

a Lymph node histology showing EBV-driven lymphoproliferative disease with atypical Reed-Sternberg-like cells (arrow, top image), staining for CD20 (middle image) and EBV LMP1 (bottom image). b MRI brain showing high T-2 signal in right occipital lobe (top image), which persisted and was associated with underlying atrophy 4 years later (bottom images). c Lymph node histology showing diffuse large B-cell lymphoma with extensive necrosis and fibrosis (top image) and ghostly outlines of very large CD20+ cells (bottom image). d PET-CT images showing widespread adenopathy with avid FDG uptake, hepatosplenomegaly and bony uptake in the pelvis and spine (top images) with regression of nodal and bony disease post-chemotherapy (bottom images). e MRI brain showing multifocal white matter changes in the occipital and parietal lobes