TABLE 2.
KCNE1 genotypes and QT measurements from electrocardiograms of PKDF461 family members
| Individual Number | Age (Yrs) |
Gender | KCNE1: p.Tyr46* | QT (msec) | HR (bpm) | QTcB (msec) |
QTcF (msec) |
|---|---|---|---|---|---|---|---|
| IV-6 | 49 | Male | +/− | 410 | 63 | 420 | 417 |
| IV-1 | 45 | Female | +/− | 400 | 78 | 456 | 437 |
| V-2 | 15 | Female | +/+ | 360 | 111 | 490 | 442 |
| V-5 | 13 | Female | −/− | 460 | 73 | 507 | 491 |
|
V-4 (Resting) |
18 | Male | −/− | 480 | 66 | 503 | 495 |
|
V-4 (under exercise) |
18 | Male | −/− | 360 | 119 | 507 | 452 |
| V-6 | 20 | Male | +/+ | 400 | 80 | 462 | 440 |
| V-7 | 28 | Female | −/− | 430 | 87 | 518 | 487 |
+ is the wild type allele, - is the p.Tyr46* nonsense mutation
B = Bazett’s formula, F = Fridericia’s formula
upper limit for normal range QT interval for women = 460 ms, man = 450 ms and for a child = 440 ms