Table 4.

Cox Proportional Hazards—Additive Effects for Sleep Disturbance × e4 Carrier Status: Outcome: Probable AD.

	Sleep disturbance × e4 carrier(unadjusted)	Sleep disturbance × e4 carrier adjusteda with demographics	Sleep disturbance × e4 carrier adjustedb with demographics and AD medication use
	Hazard ratio (95% Cl)	Hazard ratio (95% Cl)	Hazard ratio (95% Cl)
Sleep disturbance × e4 carrier	3.02 [1.77,5.13]***	4.83 [2.90, 8.03]***	4.38 [2.54, 7.55]***
Use of sleep medication (general)	3.57 [1.26, 10.1]**	4.61 [1.76, 12.1]***	2.40 [0.49, 11.7]
Did not use sleep medication	2.80 [1.51, 5.20]***	4.80 [2.58, 8.92]***	4.70 [2.50, 8.85]***
Trazodone use	1.64 [0.41, 6.65]	1.64 [0.60,4.46]	0.79 [0.15,4.11]
No trazodone use	3.10 [1.75, 5.50]***	5.11 [2.88,9.05]***	5.03 [2.81,9.03]***
Zolpidem use	6.43 [1.39,29.7]**	7.82 [1.56, 39.1]**	12.0 [2.28,63.4]***
No zolpidem use	2.81 [1.59,4.95]***	4.54 [2.64, 7.78]***	4.16 [2.34,7.39]***

Note. AD = Alzheimer’s disease; CI = confidence interval.

^aAdjusted for sex, age, education, race, and Hispanic origin.

^bAdjusted for sex, age, education, race, Hispanic origin, and AD medication use. *p < .1.

^**p < .05.

^***p < .01.