Figure 1.

Schematic diagram depicting differences between PLA2G1B and PLB activities in the digestive tract. Lipolytic enzymes secreted by the pancreas, including pancreatic triacylglycerol lipase (PTL), carboxyl ester lipase (CEL) and PLA2G1B catalyze the hydrolysis of lipid droplets in intestine lumen near the duodenum and jejunum region, liberating free fatty acid (FFA), cholesterol (CH), and lysophospholipids such as lysophosphatidylcholine (LPC) for absorption into the intestine. The FFA and CH are used for triacylglycerol and cholesterol ester synthesis and packaged into chylomicrons (chylo’s) for secretion into the plasma. The phospholipase B (PLB) catalyzes similar process in the ileum area but generates glycerylphosphoryl choline (GPC) instead of lysophospholipids.