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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Jul 9;1864(6):784–788. doi: 10.1016/j.bbalip.2018.07.001

Figure 2.

Figure 2.

Schematic diagram comparing intestinal helminth infection in Pla2g1b+/+ and Pla2g1b−/− mice. After ingestion of the worm, the larvae penetrates the intestinal epithelium into the mucosa. In Pla2g1b+/+ mice, PLA2G1B hydrolyzes the larval phospholipids to enable trapping of the larvae by Th2 cells and killing of the helminth. In Pla2g1b−/− mice, Th2 killing of helminth is ineffective due to lack of larval phospholipid hydrolysis. The larvae can germinate to adult worm and reinfection of the gut epithelium.