Table 1.

Summary of Topical Hemostatic Agents

Type	Class	Brand Name(s)	Mechanism of Action
Absorbable Agents	Oxidized Regenerated Cellulose (ORC)*	Surgicel®	Creates scaffold for platelet aggregation
		Original®	Bactericidal properties
		NuKnit®
		Fibrillar™
		SNoW®
	Microfibrillar Collagen (MFC)	Avitene®	Creates scaffold for platelet aggregation
		Avitene Ultrafoam
		Avitene UltraWrap
		Endo-Avitene
		Helistat
		Helitene®
	Microporous Polysaccharide	Arista™	Absorbs water and other low molecular weight compounds from the blood and concentrates these component to form platelet plug
	Gelatin	Gelfoam®	Gelatin matrix:
		Surgifoam®	Absorbs surrounding blood, increasing the agent's size and weight
Biologic Agents	Topical Thrombin	Thrombin-JMI®	Topical thrombin:
		Evithrom®	Converts fibrinogen to fibrin
		Recothrom®	Activates platelets, aiding in formation of platelet plug
	Topical Thrombin + Gelatin	Thrombi-Gel®	Topical thrombin:
			Converts fibrinogen to fibrin
			Activates platelets, aiding in formation of platelet plug
			Gelatin matrix:
			Absorbs surrounding blood, increasing the agent's size and weight
	Topical Thrombin + Gelatin	Floseal®*	Topical thrombin:
		Surgiflo®	Converts fibrinogen to fibrin
			Activates platelets, aiding in formation of platelet plug
			Gelatin matrix:
			Absorbs surrounding blood, increasing the agent's size and weight
	Fibrin Sealant*	Tisseel®	Comprised of two components:
		TachoSil®	Sealer protein solution
		Evicel®	Contains aprotinin, factor XIII and fibrinogen
			Thrombin solution
			Converts fibrinogen in protein solution to fibrin
			Contains calcium chloride

^*These agents are discussed in the included articles.