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. 2019 Jan 9;12(3):550–560. doi: 10.1016/j.tranon.2018.12.007

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© 2018 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

MIG-6 can substratify patients beyond the CRS. Patients divided into low-CRS (0-2) and high-CRS (3-5) groups were further stratified by median MIG-6 expression. (A) Within the low-CRS group, patients were separated into two groups: those in the upper 50th percentile of MIG-6 expression and those in the lower 50th percentile. The median overall survival was 33 months in the upper–MIG-6 subgroup and was not reached in the lower–MIG-6 group (P = .03). (B) Similarly, within the high-CRS group, patients were separated into two groups: those in the upper 50th percentile of MIG-6 expression and those in the lower 50th percentile. The median overall survival in the upper– and lower–MIG-6 subgroups was 18 and 33 months, respectively (P = .04). Numbers below the figure are life tables designating how many patients are represented in the survival curves.