Table 4.
Results of Univariate Association of Clinicopathologic Variables with Overall Survival
| Variable | n | Median Survival (Months) | Hazard Ratio | 95% CI | P Value |
|---|---|---|---|---|---|
| Age | 26 | 68 | 0.63 | 0.33-1.18 | .15 |
| <60 | |||||
| ≥60 | 30 | 36 | |||
| Sex | |||||
| Female | 18 | 37 | 0.88 | 0.46-1.70 | .71 |
| Male | 38 | 32 | |||
| Date of hepatectomy | |||||
| After January 1, 2000 | 19 | 29 | 1.28 | 0.65-2.71 | .44 |
| Before January 1, 2000 | 37 | 40 | |||
| Primary tumor site | |||||
| Colon | 47 | 36 | 1.03 | 0.46-2.34 | .94 |
| Rectum | 9 | 51 | |||
| Disease-free interval | |||||
| Metachronous | 23 | 54 | 0.61 | 0.33-1.17 | .14 |
| Synchronous | 33 | 33 | |||
| Hepatic lobe involvement | |||||
| Unilobar | 40 | 36 | 1.32 | 0.66-2.58 | .44 |
| Bilobar | 16 | 36 | |||
| Primary tumor node status | |||||
| N0 | 14 | 43 | 0.84 | 0.42-1.69 | .63 |
| N1 | 41 | 36 | |||
| Preoperative CEA | |||||
| <200 ng/ml | 39 | 33 | 1.37 | 0.52-3.44 | .55 |
| ≥200 ng/ml | 6 | 65 | |||
| Diameter of largest met | |||||
| <5.0 cm | 28 | 58 | 0.50 | 0.25-0.91 | .03 |
| ≥5.0 cm | 28 | 30 | |||
| Number of metastases | |||||
| Solitary | 27 | 54 | 0.57 | 0.30-1.05 | .07 |
| Multiple | 29 | 29 | |||
| Hepatectomy EBL | |||||
| <1000 ml | 30 | 36 | 1.16 | 0.62-2.19 | .64 |
| ≥1000 ml | 25 | 33 | |||
| Hepatectomy margin | |||||
| <1.0 cm | 27 | 40 | 1.11 | 0.59-2.08 | .74 |
| ≥1.0 cm | 29 | 31 |
Preoperative CEA level was not obtained in 13 patients. Primary tumor nodal status was unknown in two patients. CEA, carcinoembryonic antigen; met, metastasis.