Table 5.

Univariate Analysis of Candidate Genes

Candidate Gene Expression	n	Median Survival (mos)	Hazard Ratio (95% CI)	P Value Survival	Median LDFS (mos)	Hazard Ratio (95% CI)	P Value LDFS
LUM
Low	28	50	0.64	.19	51	0.55	.10
High	27	32	(0.30-1.28)		20	(0.24-1.14)
TIMP1
Low	28	57	0.60	.14	51	0.51	.07
High	28	31	(0.29-1.19)		20	(0.23-1.06)
BHLHB2
Low	28	57	0.59	.13	NR	0.55	.11
High	28	31	(0.28-1.17)		27	(0.26-1.16)
FN1
Low	28	57	0.63	.18	46	0.80	.54
High	28	31	(0.30-1.26)		27	(0.37-1.69)
TM4SF1
Low	28	42	0.90	.77	46	0.94	.86
High	28	31	(0.44-1.83)		27	(0.44-1.99)
Mig-6
Low	28	67	0.42	.01	NR	0.55	.10
High	28	29	(0.18-0.80)		20	(0.24-1.12)
SER2
Low	28	42	0.79	.50	46	0.76	.47
High	27	31	(0.38-1.61)		20	(0.35-1.62)

Quantitative RT-PCR was performed on colorectal liver metastases from 56 additional patients that underwent hepatectomy. Patients above and below the median expression level were compared by log-rank testing.