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. 2019 Jan 4;12:498. doi: 10.3389/fncel.2018.00498

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Copyright © 2019 Xu, Xing, Huang, Zhou, Liu, Cui, Cheng, Wang, Zhou, Yang, Yang, Zhang, Zang, Ma and Guan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HDAC1-silenced MSCs rescued impaired neural function after TBI. (A) Quantitative analysis of extravasated evans blue (EB) dye in the ipsilateral cerebral hemisphere tissue of mice at 3 days after TBI. (B) Quantification of lesion volume and (C) representative images of cresyl violet (CV) staining, Scale bar = 1 mm. (D) Body weight, (E) modified neurologic severity score (mNSS) scores. (F) Representative tracings from the Morris water maze (MWM) test of the mice. Escape latency (G), platform crossing numbers (H), and time in the target quadrant (I) were measured using MWM test. (J) Forced swim test (FST), (K) tail suspension test (TST), (L) Sucrose preference test (SPT). The data were collected from 15 mice in each group and are presented as mean ± SEM. *p < 0.05 vs. Vehicle, ^#p < 0.05 vs. MSCs.