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. 2019 Jan 4;12:498. doi: 10.3389/fncel.2018.00498

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Copyright © 2019 Xu, Xing, Huang, Zhou, Liu, Cui, Cheng, Wang, Zhou, Yang, Yang, Zhang, Zang, Ma and Guan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HDAC1-silenced MSCs increased neurogenesis in the hippocampus of TBI mice. (A) Representative immunofluorescent images. (B) Quantification analysis of fluorescence intensity indicated that Ki67⁺ (green), DCX⁺ (red), and NeuN⁺ (Red) cells in the dentate gyrus of hippocampus in each field, Scale bar = 200 μm. (C) Expression of BDNF, NGF, NSE, MAP2 and DCX by qRT-PCR. (D) ELISA analysis of BNDF and NGF levels at 28 day after TBI. Data were from three mice of each groups and are presented as mean ± SEM. *p < 0.05 vs. Vehicle, ^#p < 0.05 vs. MSCs.