Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jan 4;9:3083. doi: 10.3389/fimmu.2018.03083

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Hu, Tian, Ding and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

The functions of CHOP in exogenous-pathway-induced apoptosis. CHOP triggers the extrinsic apoptotic pathway through the upregulation of DR4 and DR5. PERK can induce ATF4 expression, which results in CHOP and ATF3 expression. CHOP and ATF3 then bind to the promoters of the DR4 and DR5 genes, upregulating their expression. TRAIL combining with DR4 and DR5 regulates the caspase 8-mediated cascade, which activates caspase3/7 to lead apoptosis. On the other hand, Bid is cleavaged into tBid. tBid then regulates the BAX-BAK-mediated mitochondrial apoptosis pathways.