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. 2019 Jan 4;8:655. doi: 10.3389/fonc.2018.00655

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Copyright © 2019 Yu, Tang, Lin, Yao and Shen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Knockdown of DGKZ suppresses tumourigenesis in an osteosarcoma xenograft nude mouse model: (A) Photograph shows the representative BALB/c nude mice bearing xenograft tumors formed by HOS osteosarcoma cells with or without DGKZ silencing in the same mice for comparison. (B) Growth curve of tumors in mice for duration of 4 weeks. DGKZ-knockdown formed significant smaller tumors than the control group (n = 10 for both). (C) Representative bioluminescent images of mice without DGKZ-silencing before sacrificed, as shown by intensive bioluminescent signals detected. (D) Representative bioluminescent images of mice with DGKZ-silencing before sacrificed, no bioluminescent signal was visualized. (E) Progression of BLI over time indicated significant difference between control group and DGKZ -knockout mice. (F) Photograph shows the dissected osteosarcoma tumors formed in host mice. (G) Significant smaller tumors were formed by DGKZ-silencing in xenograft.