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. 2019 Jan 4;6:640. doi: 10.3389/fchem.2018.00640

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Copyright © 2019 Hitzenberger and Zacharias.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(Left panel) TMDs of γ-secretase with strongly immobilized lipids. The TMDs of PS-1 are colored in dark blue, PEN-2 is depicted in beige, APH-1 in red and nicastin in gray. The lipids are colored according to their B-factor: Cyan: 156 to 250Å²; orange: 405 to 519Å²; green: 610 to 732Å²; purple: 785 to 1026Å². The active site residues D257 and D385 are marked by red dots. (Right panel) Van der Waals surface depiction of presenilin-1 with the strongly bound POPC molecule in the cavity.