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(A) Backbone RMSD with respect to the first frame in the trajectory. Green: nicastrin TMD; black: PS-1 TMDs; blue: all TMDs. (B) Backbone RMSDs of the split trajectory. Black: PS-1 TMDs (inactive conformation); red: all TMDs (inactive conformation); green: PS-1 TMDs (active conformation); blue: all TMDS (active conformation).
