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. 2019 Jan 4;9:1840. doi: 10.3389/fpls.2018.01840

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Copyright © 2019 Tugizimana, Djami-Tchatchou, Steenkamp, Piater and Dubery.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Metabolic network analysis: A biochemical and empirical network displaying metabolic relationship patterns between metabolites indicated by OPLS-DA as signatory biomarkers. Metabolites are connected based on biochemical relationships (red, KEGG RPAIRS) or structural similarity (blue); as also indicated on the network descriptive legend (left-side). Metabolite color represents relative change (red: increase; green: decrease) in infected plants compared to non-infected sorghum plants. The different shapes indicate the metabolites' molecular classes or biochemical domains. The graph was visualized with Cytoscape version 3.5.0. Applying a Tanimoto coefficient ≥0.7 for structural similarity, the resultant graphic representation and computed network parameters (e.g., clustering coefficient of 0.695; network density of 0.573) revealed a high interconnectivity of the OPLS-DA selected metabolites.