S3.

Mean age of diagnosis of liver cancer, by gender and areas in 22 cancer registries

Period	Year	22 registries			Urban			Rural
		Male	Female		Male	Female		Male	Female
2000−04	2000	58.80	64.02		59.67	65.35		56.53	60.60
	2004	59.35	64.66		59.82	65.50		57.83	62.57
	Changing	0.55	0.64		0.15	0.15		1.30	1.97
2005−09	2005	59.40	65.66		59.78	66.47		57.98	63.07
	2009	60.40	67.00		60.66	67.78		59.31	64.33
	Changing	1.00	1.34		0.88	1.31		1.33	1.26
2010−14	2010	60.88	67.33		61.39	67.97		58.96	65.19
	2014	62.35	68.99		62.66	69.87		61.20	66.07
	Changing	1.47	1.66		1.27	1.90		2.24	0.88
2000−14	2000	58.80	64.02		59.67	65.35		56.53	60.60
	2014	62.35	68.99		62.66	69.87		61.20	66.07
	Changing	3.55	4.97		2.99	4.52		4.67	5.47
	t	18.70	20.50		11.52	11.69		17.35	11.14
	P	< 0.001	< 0.001		< 0.001	< 0.001		< 0.001	< 0.001