3.
PK parameters of exemestane and chidamide
| Parameters | Exemestane (n=19) (
 )
|
Chidamide (n=18) (
 )
|
|||
| Exemestane | Chidamide plus exemestane | Chidamide | Exemestane plus chidamide | ||
| PK, pharmacokinetic; Cmax, maximum plasma drug concentration; Tmax, time to reach maximum concentration; AUC, area under curve; Vd/F, volume of distribution; CL/F, clearance. | |||||
| Tmax [median (range)] (h) | 1.0 (1.0−4.0) | 1.0 (1.0−4.0) | 2.0 (1.0−12.0) | 2.0 (1.0−12.0) | |
| Cmax (ng/mL) | 32.5±17.6 | 31.4±13.2 | 140.3±93.1 | 147.7±84.7 | |
| AUC0−t (ng·h/mL) | 71.8±26.3 | 79.3±28.6 | 1,785.2±944.7 | 2,230.8±973.2 | |
| AUC0−∞ (ng·h/mL) | 75.1±25.8 | 84.1±30.3 | 1,911.3±1,017.0 | 2,386.4±1,013.6 | |
| t1/2 (h) | 6.5±7.3 | 5.4±2.6 | 18.3±4.7 | 17.3±3.7 | |
| Vd/F (L) | 3,622.6±5,614.2 | 2,519.4±1,498.6 | 506.3±215.6 | 365.7±153.1 | |
| CL/F (L/h) | 370.7±120.2 | 337.3±129.2 | 19.8±9.0 | 14.8±6.3 | |