2.

Top 10 significantly down-regulated and up-regulated circRNAs in UM tissues ranked by FC

circRNA ID	P	FC	Regulation	Chromosome	Strand	Gene symbol
circRNA, circular RNA; UM, uveal melanoma; FC, fold change; circRNA ID was based on circBase (http://www.circbase.org/); TRPM3, transient receptor potential cation channel subfamily M member 3; SLC16A14, solute carrier family 16 member 14; NRXN1, neurexin 1; KCNH5, potassium voltage-gated channel subfamily H member 5; ABI3BP, ABI family member 3 binding protein; DLG2, discs large MAGUK scaffold protein 2; RASGRP3, RAS guanyl releasing protein 3; RTTN, rotatin; NT5DC3, 5’-nucleotidase domain containing 3; GALNT3, polypeptide N-acetylgalactosaminyltransferase 3.
Top 10 down-regulated circRNAs
hsa_circ_0138941	0.0003893	283.763	Down	Chr9	−	TRPM3
hsa_circ_0138937	0.0007409	269.396	Down	Chr9	−	TRPM3
hsa_circ_0138940	0.0007775	235.564	Down	Chr9	−	TRPM3
hsa_circ_0119311	0.0003781	234.496	Down	Chr2	−	SLC16A14
hsa_circ_0138938	0.0002563	195.268	Down	Chr9	−	TRPM3
hsa_circ_0054525	0.0003071	167.859	Down	Chr2	−	NRXN1
hsa_circ_0138943	0.0007409	164.587	Down	Chr9	−	TRPM3
hsa_circ_0102350	0.0005263	164.385	Down	Chr14	−	KCNH5
hsa-circRNA13657-1	0.0018337	161.768	Down	Chr3	−	ABI3BP
hsa_circ_0096593	0.0022401	146.897	Down	Chr11	−	DLG2
Top 10 up-regulated circRNAs
hsa_circ_0119872	0.0005712	45.064	Up	Chr2	+	RASGRP3
hsa_circ_0108830	0.0017993	26.919	Up	Chr18	−	RTTN
hsa-circRNA4393-3	0.0004631	26.719	Up	Chr2	+	RASGRP3
hsa_circ_0097065	0.0005249	26.481	Up	Chr12	−	NT5DC3
hsa_circ_0053943	0.0007234	26.189	Up	Chr2	+	RASGRP3
hsa_circ_0056902	0.0027034	26.141	Up	Chr2	−	GALNT3
hsa-circRNA10088-5	0.0008077	25.652	Up	Chr12	−	NT5DC3
hsa_circ_0119871	0.0003551	25.067	Up	Chr2	+	RASGRP3
hsa-circRNA10088-11	0.0008296	24.219	Up	Chr12	−	NT5DC3
hsa-circRNA11838-9	0.0028436	24.061	Up	Chr18	−	RTTN