Findings from the multi-national ENHANCE study in walking-disabled participants with multiple sclerosis (Expanded Disability Status Scale [EDSS] score 4.0−7.0) showed that participants treated with prolonged-release (PR)-fampridine 10 mg twice daily were more likely than those treated with placebo to achieve clinically meaningful improvements in self-reported walking ability over 24 weeks.

PR-fampridine was also associated with benefits in objectively measured mobility and self-reported physical functioning.

Additional research is required to better understand the pathophysiologic differences in individuals who do and do not respond to PR-fampridine and to evaluate the impact of PR-fampridine on manual function, cognition, and fatigue in individuals with an EDSS score > 7.0.