Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jan 10;9:30. doi: 10.1038/s41598-018-37188-0

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Chronically treated T24.6.9 melanoma cells develop a cross-resistance to both, dacarbazine and PLX4032. (A) Comparison of impedimetrically determined dacarbazine, cisplatin and PLX4032-induced IC₅₀ values after acute treatment of parental and twelve months chronically treated (1Da, 1cP, 0.1PLX) T24.6.9 cells by statistical analysis (upper panel) and linear fitting of the logarithmised IC₅₀ values (with 95% confidence intervals [dashed lines]; lower panel). (B) Overview of IC₅₀ values (µM after 72 h treatment) determined by impedance spectroscopy and XTT assay comparing parental and twelve months chronically treated cells concerning their sensitivity towards dacarbazine, cisplatin and PLX4032. (n values depicted in figure; mean ± s.e.m.; *P < 0.05; **P < 0.01; ***P < 0.001); Dacarb = dacarbazine; 1Da = long-term 1 µM dacarbazine-treated cells; cisPt = cisplatin; 1cP = long-term 1 µM cisplatin-treated cells; 0.1PLX = long-term 0.1 µM PLX4032-treated cells; XTT = tetrazolium salt-based cytotoxicity assay.