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. 2019 Jan 10;9:31. doi: 10.1038/s41598-018-37251-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Expression of ITGB1 and BLNCR is regulated by p63 and AP-1 factors. (a) ChIP-sequencing tracks of p63, RNA pol II and H3K27ac signal in promoter region of BLNCR and ITGβ1 during a time-course of differentiation; day 0, 2, 4 and 7¹². Non-differentiated NHEK H3K4me3 and H3K4me1 tracks from ENCODE, DNase clusters (ENCODE, 125 cell types) and transcription factor ChIP-seq tracks (ENCODE transcription factor ChIP-seq, 161 factors, with Factorbook Motifs) are also included. (b) 18s normalized expression of indicated genes in p63 knockdown samples. Percentage knockdown p63: 82,5%. n = 3, mean −/+ SD. Statistical significance was assessed using a t-test: *p < 0,05; **p < 0,01; ***p < 0.001. (c) 18s normalized expression of indicated genes after 24 or 48 hours of AP-1 inhibition using tanshinone IIA. n = 3, mean −/+ SD. Statistical significance was assessed using a t-test: *p < 0,05; **p < 0,01; ***p < 0.001.