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. 2019 Jan 10;10(1):31. doi: 10.1038/s41419-018-1241-2

Fig. 1. Resistin promotes VEGF-A production and angiogenesis in human chondrosarcoma.

Fig. 1

a–d Chondrosarcoma cells were incubated with resistin (0.3–30 ng/ml) for 24 h or stimulated with resistin (30 ng/ml) for indicated time intervals; VEGF-A expression was examined by qPCR and ELISA. e–g Chondrosarcoma cells were incubated with resistin for 24 h then stimulated with VEGF-A, VEGF-C, or IgG antibody (1 μg/ml) for 30 min. The conditioned medium (CM) was then collected and applied to endothelial progenitor cells (EPCs). EPCs tube formation and migration were measured (Size bar = 200 μm). Results are expressed as the mean ± SEM. *p < 0.05 as compared with the control group; #p < 0.05 as compared with the resistin-treated group