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. 2019 Jan 10;9:20. doi: 10.1038/s41598-018-36923-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Isometric paternal age at conception midpoint (PACmp), relative to year 500 (iso-PAC500) vs. birth telomere length (TL) Equilibrium. Simulations are performed for mean birth TL between 6,000–15,000 bp in the founding population for models with 1-Fold (blue), 2-Fold (yellow), and 4-Fold (green) cancer scaling factors. iso-PAC500 is taken as the PACmp for which mean transgenerational TL is unchanged between years 500 and 1000. Results are fit to a logistic curve and plotted for TL ranging between 6,000 and 12,000 bp.