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. 2019 Jan 10;10(1):25. doi: 10.1038/s41419-018-1242-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Extracellular acidic upregulated the expression of CYP24A1 and increased the activity of mitochondrial respiration. Meanwhile, CYP24A1 over-expression leads to the degradation of 1α,25(OH)₂D₃. While 1α,25(OH)₂D₃ could inhibit the cancer stem cell phenotype of stem cell-like glioma cells as well as impair the mitochondrial respiration